What is INREBIC® (fedratinib)?
INREBIC is a prescription medicine used to treat adults with certain types of myelofibrosis (MF). It is not known if INREBIC is safe and effective in children.
Pricing Information
Like many patients, knowing what you may pay for treatment can be a major concern. That’s why Bristol Myers Squibb (BMS) is committed to helping you understand your out-of-pocket (OOP) costs and possible resources that may help make them more affordable.
The information below will help you understand not only the list price of your medication, but what your out-of-pocket (OOP) costs might be based on your insurance coverage.
The list price of INREBIC is $27,600 when given as 400 mg once daily for a
*As of January 2025, for a 30-day supply. List price is also known as wholesale acquisition cost, or WAC.
†WAC is the price at which pharmaceutical manufacturers sell their products to wholesalers. WAC does not take into account discounts that may be available to insurers or other intermediaries, nor does it reflect the value of patient assistance programs or copay support programs. Most people do not pay the list price for INREBIC.
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If you have commercial insurance
You could pay as little as $0 per month with the BMS Co-Pay Assistance Program.
Learn about this program. -
If you have Medicare
You could pay $0–$66 per month if you are receiving INREBIC 400 mg daily (depending on your specific Medicare benefits); 75% of Medicare patients pay $0 per month. For INREBIC, your costs are determined by your pharmacy coverage such as Medicare Part D or Medicare Advantage (a.k.a., Part C), your coverage phase, and your income level. Use this link to learn about costs for Medicare drug coverage. Certain patients may be eligible for Low-Income Subsidy, also known as “Extra Help.” Use this link to learn more.
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If you have Medicaid
You could pay $0–$20 per month (depending on state plan). To find out if you qualify for Medicaid, or to get more information about co-payments in your state, please use this link to visit the Medicaid website.
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If you do not have insurance coverage
If you do not have medical coverage, or if your insurance does not cover INREBIC, you can expect to pay the list price shown above. Patients without insurance are encouraged to call 1-800-861-00481-800-861-0048 to explore potential options.
For additional information, the BMS Access Support® Program provides resources to help patients understand their insurance coverage and find information on sources of financial support.
The BMS Co-Pay Assistance program may help eligible commercially insured patients pay up to $10 per month. BMS will cover the rest of the cost, up to $15,000 per year per product.
Please visit BMS Access Support or call 1-800-861-00481-800-861-0048, 8 AM–8 PM ET, Monday–Friday.
Important Safety Information
WARNING: ENCEPHALOPATHY INCLUDING WERNICKE’S
What is the most important information I should know about INREBIC® (fedratinib)?
INREBIC may cause serious side effects, including:
- Encephalopathy (including Wernicke’s encephalopathy). A serious and sometimes fatal neurological problem called encephalopathy (including Wernicke’s encephalopathy) has happened in some people who take INREBIC. Wernicke’s encephalopathy is a neurologic emergency that can happen if you do not have enough vitamin B1 (thiamine) in your body. Your healthcare provider will do a blood test to check your vitamin B1 level before starting and during treatment with INREBIC. Your healthcare provider may tell you to stop taking INREBIC and take a vitamin B1 supplement if you develop side effects during treatment with INREBIC.
Call your healthcare provider right away if you develop diarrhea, nausea, or vomiting that does not respond to treatment.
Get emergency medical help right away if you develop the following:
- confusion, memory problems, or drowsiness
- problems with balance and movement, such as difficulty walking
- eye problems, such as double or blurred vision or abnormal eye movements
Call your healthcare provider if you experience rapid weight loss or weight loss that does not get better with treatment.
Before taking INREBIC, tell your healthcare provider about all your medical conditions, including if you:
- have low red blood cell or platelet counts
- have or have had liver problems
- have or have had kidney problems
- have had cancer in the past
- are a current or past smoker
- have had a blood clot, heart attack, other heart problems, or stroke
- are breastfeeding or plan to breastfeed. It is not known if INREBIC passes into your breast milk. You should not breastfeed during treatment with INREBIC and for at least 1 month after your last dose. Talk to your healthcare provider about the best way to feed your baby during treatment with INREBIC.
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
INREBIC and other medicines may affect each other causing unwanted side effects. Know the medicines you take. Keep a list of them to show your healthcare provider and pharmacist when you get a new medicine.
How should I take INREBIC?
- Take INREBIC exactly as your healthcare provider tells you to. Do not change your dose or stop taking INREBIC unless your healthcare provider tells you to.
- Take INREBIC 1 time each day.
- Take INREBIC with or without food. Taking INREBIC with a high fat meal may help to reduce nausea and vomiting symptoms.
- If you miss a dose of INREBIC, skip the missed dose and take your next dose at your regular time. Do not take 2 doses to make up for the missed dose.
What are the possible side effects of INREBIC?
INREBIC can cause serious side effects, including:
- Low blood cell counts. INREBIC may cause low red blood cell counts (anemia) and low platelet counts (thrombocytopenia) in some people. You may need a blood transfusion if your blood counts drop too low. Your healthcare provider will do blood tests to check your blood counts before you start and during treatment with INREBIC. Tell your healthcare provider if you develop any bleeding or bruising during treatment with INREBIC.
- Nausea, vomiting, and diarrhea. Your healthcare provider may give you certain medicines to help treat your nausea, vomiting, and diarrhea. Call your healthcare provider or get emergency medical help right away if you have nausea, vomiting, or diarrhea that does not get better with treatment.
- Liver problems. Your healthcare provider will do blood tests to check your liver function before starting and during treatment with INREBIC.
- Amylase and lipase increases. You may have changes in your blood amylase or lipase levels that may indicate a problem with your pancreas. Your healthcare provider will do blood tests to check your amylase or lipase levels before starting and during treatment with INREBIC.
- Increased risk of major cardiac events such as heart attack, stroke, or death in people who have cardiovascular risk factors and who are current or past smokers while using another JAK inhibitor to treat rheumatoid arthritis.
Get emergency help right away if you have any symptoms of a heart attack or stroke while taking INREBIC, including: - discomfort in the center of your chest that lasts for more than a few minutes, or that goes away and comes back
- severe tightness, pain, pressure, or heaviness in your chest, throat, neck, or jaw
- pain or discomfort in your arms, back, neck, jaw, or stomach
- shortness of breath with or without chest discomfort
- breaking out in a cold sweat
- nausea or vomiting
- feeling lightheaded
- weakness in one part or on one side of your body
- slurred speech
- Increased risk of blood clots. Blood clots in the veins of your legs (deep vein thrombosis, DVT) or lungs (pulmonary embolism, PE) have happened in people taking another JAK inhibitor for rheumatoid arthritis and may be life-threatening.
Tell your healthcare provider right away if you have any signs and symptoms of blood clots during treatment with INREBIC, including: - swelling, pain, or tenderness in one or both legs
- sudden unexplained chest or upper back pain
- shortness of breath or difficulty breathing
- Possible increased risk of new (secondary) cancers. People who take another JAK inhibitor for rheumatoid arthritis have an increased risk of new (secondary) cancers, including lymphoma and other cancers. People who smoke or who smoked in the past have an added risk of new cancers.
The most common side effects of INREBIC include:
- diarrhea
- nausea
- low red blood cell counts (anemia)
- vomiting
These are not all of the possible side effects of INREBIC.
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-10881-800-FDA-1088.
Indication
What is INREBIC® (fedratinib)?
INREBIC is a prescription medicine used to treat adults with certain types of myelofibrosis (MF). It is not known if INREBIC is safe and effective in children.
Please see full Prescribing Information for INREBIC including Boxed WARNING and
Important Safety Information
WARNING: ENCEPHALOPATHY INCLUDING WERNICKE’S
What is the most important information I should know about INREBIC?
INREBIC may cause serious side effects, including:
- Encephalopathy (including Wernicke’s encephalopathy). A serious and sometimes fatal neurological problem called encephalopathy (including Wernicke’s encephalopathy) has happened in some people who take INREBIC. Wernicke’s encephalopathy is a neurologic emergency that can happen if you do not have enough vitamin B1 (thiamine) in your body. Your healthcare provider will do a blood test to check your vitamin B1 level before starting and during treatment with INREBIC. Your healthcare provider may tell you to stop taking INREBIC and take a vitamin B1 supplement if you develop side effects during treatment with INREBIC.
Call your healthcare provider right away if you develop diarrhea, nausea, or vomiting that does not respond to treatment.
Get emergency medical help right away if you develop the following:
- confusion, memory problems, or drowsiness
- problems with balance and movement, such as difficulty walking
- eye problems, such as double or blurred vision or abnormal eye movements
Call your healthcare provider if you experience rapid weight loss or weight loss that does not get better with treatment.
Before taking INREBIC, tell your healthcare provider about all your medical conditions, including if you:
- have low red blood cell or platelet counts
- have or have had liver problems
- have or have had kidney problems
- are breastfeeding or plan to breastfeed. It is not known if INREBIC passes into your breast milk. You should not breastfeed during treatment with INREBIC and for at least 1 month after your last dose. Talk to your healthcare provider about the best way to feed your baby during treatment with INREBIC.
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
INREBIC and other medicines may affect each other causing unwanted side effects. Know the medicines you take. Keep a list of them to show your healthcare provider and pharmacist when you get a new medicine.
How should I take INREBIC?
- Take INREBIC exactly as your healthcare provider tells you to. Do not change your dose or stop taking INREBIC unless your healthcare provider tells you to.
- Take INREBIC 1 time each day.
- Take INREBIC with or without food. Taking INREBIC with a high fat meal may help to reduce nausea and vomiting symptoms.
- If you miss a dose of INREBIC, skip the missed dose and take your next dose at your regular time. Do not take 2 doses to make up for the missed dose.
What are the possible side effects of INREBIC?
INREBIC can cause serious side effects, including:
- See “What is the most important information I should know about INREBIC?”
- Low blood cell counts. INREBIC may cause low red blood cell counts (anemia) and low platelet counts (thrombocytopenia) in some people. You may need a blood transfusion if your blood counts drop too low. Your healthcare provider will do blood tests to check your blood counts before you start and during treatment with INREBIC. Tell your healthcare provider if you develop any bleeding or bruising during treatment with INREBIC.
- Nausea, vomiting, and diarrhea. Your healthcare provider may give you certain medicines to help treat your nausea, vomiting, and diarrhea. Call your healthcare provider or get emergency medical help right away if you have nausea, vomiting, or diarrhea that does not get better with treatment.
- Liver problems. Your healthcare provider will do blood tests to check your liver function before starting and during treatment with INREBIC.
- Amylase and lipase increases. You may have changes in your blood amylase or lipase levels that may indicate a problem with your pancreas. Your healthcare provider will do blood tests to check your amylase or lipase levels before starting and during treatment with INREBIC.
The most common side effects of INREBIC include:
- diarrhea
- nausea
- low red blood cell counts (anemia)
- vomiting
These are not all of the possible side effects of INREBIC.
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-10881-800-FDA-1088.
Please see full Prescribing Information , including Boxed WARNING and
Medication Guide, for INREBIC.
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INREBIC is a trademark of Impact Biomedicines, Inc.
Access Support® is a registered trademark of
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